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Health and Science - August 14, 2025

Frightening-Looking ‘Frankenstein Bunnies’ in Colorado Not a Cause for Alarm: Scientists Explain Shope Papillomavirus Outbreak

In Fort Collins, Colorado, a peculiar sight has been causing quite a stir among locals – cottontail rabbits sporting grotesque, hornlike protrusions. However, contrary to initial alarm, these abnormalities are attributable to the Shope papillomavirus, a relatively common virus among these furry creatures.

This virus causes wart-like growths that often manifest on the faces of infected rabbits, giving an unsettling appearance reminiscent of metastasizing horns. The internet has been abuzz with various derogatory monikers for these afflicted rabbits, such as “Frankenstein bunnies,” “demon rabbits,” and “zombie rabbits.”

Despite their unsettling appearance, the virus’s influence dates back to ancient folklore and has been a subject of scientific research for nearly a century. It is believed that this virus may have played a role in the centuries-old jackalope myth prevalent in North America, which describes an animal with antlers or horns – not just rabbits.

The connection between viruses and cancer, such as the human papillomavirus (HPV) causing cervical cancer, was also advanced through research on this virus in rabbits. The Shope papillomavirus was named after Dr. Richard E. Shope, a renowned professor at The Rockefeller University who discovered the disease in cottontails during the 1930s.

Reports of these peculiar rabbits first surfaced after residents began spotting them around town and sharing photos online. Kara Van Hoose, a spokesperson for Colorado Parks and Wildlife, confirmed that the agency has been receiving calls regarding the unusual rabbits seen in Fort Collins.

However, Van Hoose emphasized that such sightings are not uncommon, especially during summer months when fleas and ticks – known carriers of the virus – are most active. The virus can be transmitted from one rabbit to another but does not pose a threat to other species, including humans and pets, according to Van Hoose.

The growths resemble warts but can appear horn-like if they extend beyond a certain length. While these growths do not typically harm the rabbits, they can cause issues if they obstruct eating due to their location around the eyes or mouth. Fortunately, rabbits’ immune systems are equipped to fight off the virus, and once they do, the growths will disappear, Van Hoose assured.